The SI-LANGWH isolated working heart system was developed for in vitro measurements of the mechanical activity and work performed by hearts from small animals according to the methods devised by J R Neely, et al. This system is designed with a combination of features from both the classic Langendorff (non-working) and Keely (working) systems. This system includes a stainless steel sink, a small reeling pump and specially designed two-way Teflon taps.

Features:

• For use on small mammalian hearts (mouse, rat, guinea pig, hamster and rabbit)
• Working (Neely) and nonworking (Langendorff) options in the same device
• Control of the left ventricular diastolic (LVDP), coronary flow and cardiac output by variation of the left atrial filling pressure and the hydrostatic pressure in the aorta
• Measurement of the heart rate, atrial and ventricular pressure and cardiac output
• Ports for drug administration
• Pacing of the heart is possible
• Special ECG sensor available
• Tissue easily removed for biochemical investigations