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Webinar : AFM Application in Single Molecule Study

Thursday 4 July 2019

Auckland (NZST) : 5:30pm
Brisbane, Sydney, Canberra, Melbourne, Hobart (AEST) : 3:30pm
Adelaide (ACST) : 3pm
Perth (AWDT) : 1:30pm

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Cells can sense, adapt to, and even remodel their extracellular microenvironment. The interplay between the cell and its environment involves multiplex signaling networks, in which many molecules dully implement their own functions. Using traditional biochemical techniques, the molecular function can only be investigated based on the averaged activities of a large amount of molecules; while single molecule techniques can provide more detailed information by resolving the structure and interaction of each individual molecule. For example, AFM can reveal how many different conformations of Aβ amyloid fibrils existing at a specific condition, and how each conformation interacts with the monomeric protein. The monomer-monomer or monomer-fibril interaction variation can be monitored in-situ while the environmental conditions (e.g., pH and ionic strength) are changed.

On the other hand, force has been utilised by nature to drive protein conformational changes, therefore modulate its stability and functionality. Such mechanical mechanisms are widely involved in physiological events at cellular level. To understand these mechanisms at the molecular level, it is necessary to manipulate single bio-molecules and resolve sub-pN forces. Thanks to recent improvements in spatial, temporal, and force resolutions, AFM and optical tweezers are capable to address the above requests. Now the single molecule stretching and rupture events can be directly resolved with sub-nm distance and pN force resolutions. The mechanical stability of processive motors (e.g., kinesin and myosin) have been widely studied with optical tweezers. Subtle forces have been applied on ion-binding proteins and antigen-antibody complexes to understand the mechanical effect on the binding affinity.

In this webinar, Bruker will share the recent technological developments in this field and some examples in molecular applications of AFM and optical tweezers.

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New Sapphire Single Frequency Lasers

With 50,000 installations, Sapphire is one of the most successful products in the laser industry.

Recently released to the Sapphire family are two high power models in the range of single frequency lasers.

  • Sapphire 488nm SF up to 150mW, FP up to 100mW
  • Sapphire 532nm SF up to 200mW, fibre pigtailed up to 150mW

Sapphire SF lasers are intended for applications that need narrow and ultra-narrow linewdith such as Raman spectroscopy, inteferometry, holography, metrology and inspection.

For further information please contact us or download the datasheet.

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Webinar : Evaluate Surface Coating Mechanical and Frictional Properties

Thursday 27 June 2019

 

New Zealand (NZST) : 5:30pm
Brisbane/Sydney/Canberra/Melbourne/Hobart (AEST) : 3:30pm
Adelaide (ACST) : 3pm
Perth (AWST) : 1:30pm

 

Register

In the modern engineering community there is a growing need to reduce friction, wear rate and increase durability of the mechanical components. Traditionally these problems were resolved by changing the bulk materials or by utilising lubrications. The recent development in surface engineering fueled by our understanding of the importance of surface properties on tribology and development of new coating and treatment methods have provided another approach to friction and wear control. From biomedical to optical and from microelectronics to decorative applications, coating now plays a major role. 

In this webinar presented by Bruker Nano Surfaces we investigate the measurement and characterisation of surface coatings and their mechanical properties. Specifically we will look in to characterising the adhesion strength between coating and the substrate and the hardness of the coatings. We will also touch on wear and lifetime characterisation of the coated surfaces.

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Next Generation Benchtop SEM

The advanced technology and functions in the new NeoScopeTM from JEOL (model JCM-7000) make it simple for users at any skill level to obtain outstanding SEM images and elemental analysis results in minutes.

The new NeoScope produces high magnification up to 100,000X with large depth of field. It features a large sample chamber, high and low vacuum modes, secondary and backscatter electron detectors, real-time 3D imaging, highly-advanced auto functions and the option to add a fully-embedded EDS with real-time, " Live"  analysis.

For further information please contact us or read more.

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Introducing the Nikon SoRa High Speed SR SD Confocal Microscope

Nikon has released their new SoRa high speed super-resoution microscope.

Based on a Yokogawa CSU-W1 spinning disc confocal platform the SoRa achieves 120nm lateral resolution through optical pixel realignment.

When combined with Nikon's award winning Eclipse Ti2-E inverted microscope and NIS-Elements software the system provides a high-speed, super-resolution microscope with powerful image automation and acquisition via Nikon JOB's and HCA functionality for super-resolution live-cell imaging.

The system includes two spinning discs which can be exchanged easily via software control - a super reolution disc which also includes the capability of optical sectioning, and a standard confocal imaging disc.

For further information please contact Andrew Masters or read more.

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