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Bruker Launches Large-Format Bio-AFM System

The new NanoWizard® 4 XP High Resolution, Large-Format Bio-AFM integrates Bruker's exclusive PeakForce Tapping, which enables both superior force control and unparalleld AFM ease of use, and industry-leading QI mode for high-resolution nanomechanics on soft samples.

Building on JPK's pioneering role in combining AFM with advanced optical techniques, the NanoWizard 4 XP system provides highest level correlative microscopy and seamless integration with phase, DIC, confocal or spinning disc microscopies, single-molecule methods (FRET, FCS, TIRF, FLIM, FRAP), super-resolution tecnhniques (STED, PALM/STORM, SIM), Raman and multiphoton microscopy.

In addition to PeakForce Tapping and QI mode, the NanoWizard 4 XP comes with JPK’s next-generation Vortis 2 high-speed, high-performance control electronics. Vortis 2 delivers the lowest noise levels and highest signal processing speeds, and it is designed to meet the needs of all operator experience levels. A revolutionary new workflow-based software GUI includes guidance, auto-setup, and workspace organization to deliver results quickly and to enhance productivity. As an option, NestedScanner™ technology enables an AFM scanning speed of 150 lines per second, unprecedented for a large-scanner system, while maintaining access to any location within all three axes. Researchers have full access to follow dynamics wherever the sample takes them, offering a true synergy with simultaneous optical microscopy. Equipped with the widest range of accessories, the NanoWizard 4 XP is the most versatile Bio-AFM system on the market, providing exceptional flexibility for novel applications and experiments.

For further information please contact us or read more.

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Solid State Illuminator for Colour Light Microscopy

The LIDA light engine is Lumencor's newest offering in a portfolio of high-performance, solid state illuminators for life sciences applications. It is designed from the ground up to work hand-in-hand with the latest monochrome cameras to generate RGB colour transmitted light images with unprecedented sensitivity, spatial resolution, speed and colour fidelity.

Conventionally, transmitted light colour images have been acquired using white light sources and colour cameras. However single-exposure acquistion of colour information comes at the expense of lower speed, less spatial resolution, reduced dynamic range and increased noise in colour cameras compared to grey-scale cameras.

The LIDA light engine integrates three solid state sources, including Lumencor's exclusive green luminescent light pipe, with the sophisticated control electronics required for high speed synchronisation of light output with camera exposure time. Transmitted light images are captured in one electroncially controlled high speed sequence.

Lumencor is excited to enable this synergistic combination of new illumination and camera technologies for histologists, clinical pathologists and anyone seeking improvements in the speed, sensitivity and precision of colour tranmistted light microscopy.

For further information please contact us or read more.

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Coherent Axon Compact Femtosecond Laser

Coherent has introduced the Axon family, a completely new suite of compact femotsecond lasers, designed from inception to deliver lower cost, reduced complexity and smaller footprint. Axon addresses demanding applications such as multiphoton microscopy (MPE), nanoprocessing, semiconductor metrology and THz spectroscopy. Axon is a fixed wavelength, compact (212mm x 312mm x 62mm), air-cooled laser. The first two models have output wavelengths of 920nm and 1064nm, with other wavelength versions expected soon. All Axon lasers feature the same form, fit and function, including 1W of average power with integrated, software-controlled GVD pre-compensation. To further simplify adaption of this laser, its output matches the existing femtosecond laser oscillators: short (<150fs) pulse width, a clean temporal profile and 80MHz pule repetition rate.

A major application of the Axon lasers is multiphoton microscopy. The 920nm laser is designed for GFP and related imaging probes, and Ca2+ indicators such as GCAMP. The 1064nm version matches well with red shifted Ca2+ indicators and red fluorescent proteins. Although MPE delivers inherent 3D images, deep penetration and high cell viablity, market adoption lags well behind confocal microscopy because the cost and size of available femtosecond lasers and the challenges of integrating them with a microscope. The combination of the optional integrated fast modulation and small laser head allows for direct attachment of Axon to a microscope scan head, potentially negating the need for an optical table.

Other applications for Axon include two-photon polymerisation, material nanoprocessing and semicondcutor and thin film metrology. The 1064nm model is also an excellent tool for supercontinuum generation thanks to its high fidelity femtosecond pulse quality.

For further information please contact us or read more.

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Webinar : AFM Application in Single Molecule Studies

Thursday 4 July 2019

            Auckland (NZST) : 5:30pm
            Brisbane, Sydney, Canberra, Melbourne, Hobart (AEST) : 3:30pm
            Adelaide (ACST) : 3pm
            Perth (AWDT) : 1:30pm


Cells can sense, adapt to, and even remodel their extracellular microenvironment. The interplay between the cell and its environment involves multiplex signalling networks, in which many molecules duly implement their own functions. Using traditional biochemical techniques, the molecular function can only be investigated based on the averaged activities of a large amount of molecules; while single molecule techniques can provide more detailed information by resolving the structure and interaction of each individual molecule. For example, AFM (Atomic Force Microscopy) can reveal how many different conformations of Aβ amyloid fibrils exist at a specific condition, and how each conformation interacts with the monomeric protein. The monomer-monomer or monomer-fibril interaction variation can be monitored in-situ while the environmental conditions (e.g., pH and ionic strength) are changed.

On the other hand, force has been utilised by nature to drive protein conformational changes, therefore modulate its stability and functionality. Such mechanical mechanisms are widely involved in physiological events at cellular level. To understand these mechanisms at the molecular level, it is necessary to manipulate single bio-molecules and resolve sub-pN forces. Thanks to recent improvements in spatial, temporal, and force resolutions, AFM and optical tweezers are capable to address the above requests. Now the single molecule stretching and rupture events can be directly resolved with sub-nm distance and pN force resolutions. The mechanical stability of processive motors (e.g., kinesin and myosin) have been widely studied with optical tweezers. Subtle forces have been applied on ion-binding proteins and antigen-antibody complexes to understand the mechanical effect on the binding affinity.

In this webinar Bruker share the recent technological developments in this field and some examples in molecular applications of AFM and optical tweezers.

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Introducing the Nikon SoRa High Speed SR SD Confocal Microscope

Nikon has released their new SoRa high speed super-resoution microscope.

Based on a Yokogawa CSU-W1 spinning disc confocal platform the SoRa achieves 120nm lateral resolution through optical pixel realignment.

When combined with Nikon's award winning Eclipse Ti2-E inverted microscope and NIS-Elements software the system provides a high-speed, super-resolution microscope with powerful image automation and acquisition via Nikon JOB's and HCA functionality for super-resolution live-cell imaging.

The system includes two spinning discs which can be exchanged easily via software control - a super reolution disc which also includes the capability of optical sectioning, and a standard confocal imaging disc.

For further information please contact Andrew Masters or read more.

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